Latest Articles on Zika Virus

  • Risk factors for neurological complications in children with Flavivirus infection Tue, 03 Aug 2021 06:00:00 -0400
    This study aims to characterize the acute neurological manifestations caused by DENV, ZIKV, and YFV during hospitalization; identify the risk factors associated with persistent neurological complications after discharge; and evaluate the time to resolution during clinical follow-up. A prospective study evaluated 505 children, between March 2014 and July 2019, hospitalized with neurological manifestations and that doctors suspected infection of the central nervous system (CNS). Viral infection of...
  • Epidemics of chikungunya, Zika, and COVID-19 reveal bias in case-based mapping Tue, 03 Aug 2021 06:00:00 -0400
    Explosive epidemics of chikungunya, Zika, and COVID-19 have recently occurred worldwide, all of which featured large proportions of subclinical infections. Spatial studies of infectious disease epidemics typically use symptomatic infections (cases) to estimate incidence rates (cases/total population), often misinterpreting them as infection risks (infections/total population) or disease risks (cases/infected population). We examined these three measures in a pediatric cohort (N≈3,000) over two...
  • NS5-independent ablation of STAT2 by Zika virus to antagonize interferon signaling Tue, 03 Aug 2021 06:00:00 -0400
    Flavivirus genus includes numerous arthropod-borne human pathogens that are clinically important. Flaviviruses are notorious for their ability to antagonize host interferon (IFN) induced anti-viral signaling. It has been documented that NS5s of flaviviruses mediate proteasome degradation of STAT2 to evade IFN signaling. Deciphering the molecular mechanism of the IFN antagonism by the viruses and reversing this antagonism may dictate anti-viral responses and provide novel antiviral approaches. In...
  • Social Stressors, Arboviral Infection, and Immune Dysregulation in the Coastal Lowland Region of Ecuador: A Mixed Methods Approach in Ecological Perspective Mon, 02 Aug 2021 06:00:00 -0400
    Aedes aegypti, the mosquito that transmits arboviral diseases such as dengue (DENV), chikungunya (CHIKV), and Zika viruses (ZIKV), is present in tropical and subtropical regions of the world. Individuals at risk of mosquito-borne disease (MBD) in the urban tropics face daily challenges linked to their socio-environment conditions, such as poor infrastructure, poverty, crowding, and limited access to adequate healthcare. These daily demands induce chronic stress events and dysregulated immune...
  • Standardization and Evaluation of an Anti-ZIKV IgM ELISA Assay for the Serological Diagnosis of Zika Virus Infection Mon, 02 Aug 2021 06:00:00 -0400
    Here, we describe the development of the in-house anti-Zika virus (ZIKV) IgM antibody capture ELISA (in-house ZIKV IgM ELISA) for the detection and diagnosis of acute ZIKV infections. We compared the in-house ZIKV IgM ELISA assay performance against two commercial kits, Euroimmun ZIKV IgM and InBios 2.0 ZIKV IgM ELISA. We tested the assays' ability to detect anti-ZIKV IgM using a well-defined serum sample panel. This panel included 80 ZIKV negative samples (20 negative, 20 found to be primary...
  • Zika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2 Mon, 02 Aug 2021 06:00:00 -0400
    The Interferon (IFN) response is crucial to restrain pathogenic infections. Investigations into flavivirus-host interactions reported that the high virulence is linked to innate immune evasion. Zika Virus (ZIKV) has developed diversified strategies to evade the innate immune system. We report that the viral protein NS2A counteracts the IFN response by strongly suppressing the IFN signaling. NS2A targets transcription factors STAT1 and STAT2, to impede their nuclear localization, thereby...
  • Spatial analysis of the incidence of dengue, Zika, and chikungunya and socioeconomic determinants in the city of Rio de Janeiro, Brazil Mon, 02 Aug 2021 06:00:00 -0400
    No abstract
  • Prevalence and trend of emerging and re-emerging arboviral infections in the state of Odisha Mon, 02 Aug 2021 06:00:00 -0400
    Newly emerging or re-emerging infections are posing continuous threat to both public health system and clinical care globally. The emergence of infections especially caused by arboviruses can be linked to several mechanisms which include geographical expansion linked to human development and transportation, global warming, enhanced transmission in peridomestic area and close proximity of human habitations to domestic as well as wild animals. The co-circulation of Dengue, Chikungunya and Zika is...
  • Prevalence of the SNP rs10774671 of the OAS1 gene in Mexico as a possible predisposing factor for RNA virus disease Mon, 02 Aug 2021 06:00:00 -0400
    CONCLUSIONS: Our population is genetically susceptible to RNA virus disease due to the predominant presence of the A allele of rs10774671 in the OAS1 gene.
  • Inhibition of Tryptophan Catabolism Is Associated With Neuroprotection During Zika Virus Infection Mon, 02 Aug 2021 06:00:00 -0400
    Zika virus (ZIKV) is an arbovirus belonging to Flaviviridae family that emerged as a global health threat due to its association with microcephaly and other severe neurological complications, including Guillain-Barré Syndrome (GBS) and Congenital Zika Syndrome (CZS). ZIKV disease has been linked to neuroinflammation and neuronal cell death. Neurodegenerative processes may be exacerbated by metabolites produced by the kynurenine pathway, an important pathway for the degradation of tryptophan,...

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